Fig. 6. (A) A photomicrograph of liver section of adult rat following administration of unadjuvanted vaccine showing histological architecture of normal liver lobular structure with central vein hepatocytes. (B) Liver section post-immunization with hyaluronic acid adjuvanted rabies vaccine illustrating a slight hepatic sinusoidal with almost normal liver architecture. (C) Liver section post-administration of purified protein derivative adjuvanted rabies vaccine showing somewhat normal liver cells and nuclei. (D) Hepatic section post-administration of alum adjuvanted vaccine revealing portal fibrosis, vacuolated cytoplasm, and cellular infiltration (H&E, ×400).
