Fig. 1.

Immunosuppression mechanism of Corticosteroids. Cytokine storm leads to the binding of cytokine in the cytokine receptor of the cell membrane, which initiates NF-κB production in the cytoplasm. NF-κB enters the nucleus to produce inflammatory proteins that get inhibited after corticosteroid implementation. Corticosteroid attaches to GR (Glucocorticoid Receptor) and transfers into the nucleus where it binds to the subunits of NF-κB and inhibits inflammatory protein production. GR also inhibits AP-1 from producing inflammatory proteins by attaching to the active site of TRE