TABLE 1.

Inhibitors and functions of Myc interaction proteins.

Interaction protein	Inhibitor	Function on Myc	Structural formula	References
CBP/p300	CPI-637	Binds to bromodomain of CBP/p300, inhibits MYC expression		Taylor et al. (2016)
	NEO2734	Induces depletion of Myc and inhibition of multiple myeloma growth		Spriano et al. (2020)
	NEO1132
WDR5	Compound 12	Strongly interrupts the interaction of WDR5-Myc complex		Chacón Simon et al. (2020)
	Compound 16	Reduces Myc recruitment to chromatin at WDR5-Myc co-bound genes		Tian et al. (2020)
P-TEFb	KL-1	Downregulates Myc and transcriptional regulated by Myc by destroying the P-TEFb complex		Liang et al. (2018)
	KL-2
	CYC065	Hinders the transcriptional activation of N-Myc by inhibiting the Cdk9 of P-TEFb		Poon et al. (2020)
	Atuveciclib (BAY 1143572)	Inhibits phosphorylation of RNAPII and reduces Myc level		Lücking et al. (2017); Narita et al. (2017)
	UNC10112785	Destabilizes and induces the substantial loss of Myc protein		Blake et al. (2019)
	SNS-032	Represses the c-Myc-dependent transcription of RhoA gene		Zhang et al. (2019)
HDAC	Vorinostat (SAHA)	Induces c-Myc acetylation at lysine 323, disrupts Myc’s transcriptional repression		Nebbioso et al. (2017)
	entinostat (MS27-275)
	Panobinostat (LBH589)	Reduces Myc protein level		Beyer et al. (2019)
	RGFP966	Remits Myc-mediated transcriptional repression of the miR-15 and let-7 families in malignant cells		Konstantinopoulos et al. (2006); Adams et al. (2016)
	depsipeptide (FK228)
	CD532	Breaks the native conformation of Aurora-A and drives the degradation of N-Myc protein		Gustafson et al. (2014)
Aurora-A	Alisertib	Disrupts the N-Myc-Aurora-A complex, inhibits N-Myc signaling		Beltran et al. (2019)
	CCT137690	Reduces N-Myc protein in a dose-dependent manner		Ommer et al. (2020)