Table 2.
Multivariable Mendelian randomization associations of vigorous physical activity with myocardial infarction risk adjusting for cardiovascular risk factors.
| Model | OR | 95% CI | p |
|---|---|---|---|
| Unadjusted model | 0.24 | 0.08–0.68 | 0.007 |
| Adjusted for BMI | 0.24 | 0.08–0.68 | 0.007 |
| Adjusted for LDL-C | 0.21 | 0.07–0.62 | 0.005 |
| Adjusted for TC | 0.21 | 0.07–0.61 | 0.004 |
| Adjusted for depression | 0.26 | 0.09–0.79 | 0.017 |
| Adjusted for T2D | 0.26 | 0.09–0.75 | 0.013 |
| Adjusted for smoking | 0.21 | 0.07–0.61 | 0.004 |
| Adjusted for vegetable consumption | 0.22 | 0.06–0.68 | 0.019 |
| Adjusted for meat consumption | 0.26 | 0.09–0.74 | 0.012 |
| Adjusted for household income | 0.23 | 0.08–0.68 | 0.008 |
| Adjusted for educational attainment | 0.22 | 0.07–0.69 | 0.009 |
Results are scaled per genetically predicted standard deviation increase of liability to vigorous physical activity. BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; SBP, systolic blood pressure; T2D, type 2 diabetes mellitus.