Figure 2.

Neutralizing antibody responses to Ad26.COV2.S vaccination

(A) Neutralization of the SARS-CoV-2 D614G pseudovirus by plasma pre- and post-vaccination from participants with no prior infection (green, n = 19) and those infected in the first (blue, n = 20) and second waves (red, n = 19). Neutralization is reflected as an ID₅₀ titer. The threshold for positivity is indicated by a dotted line

(B) Cross-reactive neutralization post-vaccination against D614G, Beta, and Delta. Pie charts show the proportion of vaccine non-responders (NR; gray), knockout of neutralization of Beta or Delta (KO; black), and the titer of 20–400 (orange), or >400 (red). The horizontal bars indicate GMT, with values indicated. Statistical analyses were performed with the Friedman test between groups and the Wilcoxon test for paired analyses. ^∗p < 0.05, ^∗∗∗p < 0.001.

(C) Fold change of post-vaccination D614G neutralization titers relative to Beta or Delta. The vertical bars indicate median fold change with error bars for IQR.