Table 1.
Differentially expressed genes (DEGs) in Ctnnb1OE−EC-LSECs compared to wild-type controls.
| Gene symbol | Gene title | Fold change Ctnnb1OE−EC > Ctnnb1WT | Adjusted p-value for Diff of genotype = Ctnnb1OE−EC–Ctnnb1WT |
|---|---|---|---|
| Slc35f2 | Solute carrier family 35, member F2 | 35.13809 | 0.000397 |
| Apln | Apelin | 10.30015045 | 0.016367 |
| Susd4 | Sushi domain containing 4 | 9.257366289 | 0.007219 |
| Csf2rb2 | Colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) | 8.781086232 | 0.041067 |
| Cd34 | CD34 antigen | 8.598926088 | 0.001273 |
| Selp | Selectin, platelet | 8.373297581 | 0.037503 |
| Lypd6 | LY6/PLAUR domain containing 6 | 8.152209698 | 0.004191 |
| Glp1r | Glucagon-like peptide 1 receptor | 7.081854471 | 0.041067 |
| Myo1b | Myosin IB | 6.942870328 | 0.023473 |
| St8sia2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 5.709992179 | 0.022697 |
| Hunk | Hormonally upregulated Neu-associated kinase | 5.184396379 | 0.045899 |
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 4.998737335 | 0.0049 |
| Atp10a | ATPase, class V, type 10A | 4.856467229 | 0.012795 |
| Tcf7 | Transcription factor 7, T cell specific | 4.800597937 | 0.013887 |
| Mal | Myelin and lymphocyte protein, T cell differentiation protein | 4.715053595 | 0.025665 |
| Ptgis | Prostaglandin I2 (prostacyclin) synthase | 4.52969164 | 0.030765 |
| Fkbp10 | FK506 binding protein 10 | 4.43037992 | 0.039368 |
| Axin2 | Axin 2 | 4.416998695 | 0.022697 |
| Pla2g16 | Phospholipase A2, group XVI | 4.319974957 | 0.039368 |
| Il17ra | Interleukin 17 receptor A | 3.86500417 | 0.031256 |
| Disp1 | Dispatched RND transporter family member 1 | 3.826121183 | 0.031256 |
| Ptgfrn | Prostaglandin F2 receptor negative regulator | 3.663983702 | 0.023473 |
| Greb1l | Growth regulation by estrogen in breast cancer-like | 3.513247405 | 0.0049 |
| Sptb | Spectrin beta, erythrocytic | 3.406728181 | 0.016367 |
| Aqp11 | Aquaporin 11 | 3.384139553 | 0.026891 |
| Extl3 | Exostoses (multiple)-like 3 | 3.381491933 | 0.037503 |
| Cttnbp2 | Cortactin binding protein 2 | 3.165960888 | 0.022697 |
| Kif21b | Kinesin family member 21B | 3.103400943 | 0.002999 |
| Fam213a | Family with sequence similarity 213, member A | 3.092980639 | 0.024278 |
| Auts2 | Autism susceptibility candidate 2 | 3.014691756 | 0.046838 |
| Tspan6 | Tetraspanin 6 | 2.872077594 | 0.046282 |
| Lrig1 | Leucine-rich repeats and immunoglobulin-like domains 1 | 2.738931683 | 0.046282 |
| Pi16 | Peptidase inhibitor 16 | 2.427155192 | 0.037503 |
| Laptm4b | Lysosomal-associated protein transmembrane 4B | 2.318212303 | 0.011483 |
| Slc7a6 | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 | 2.267050692 | 0.024407 |
| Ptprg | Protein tyrosine phosphatase, receptor type, G | 2.158891183 | 0.022697 |
| Cachd1 | Cache domain containing 1 | 2.065569075 | 0.007219 |
| Rasgrp4 | RAS guanyl releasing protein 4 | 2.057762756 | 0.045899 |
| Klhl29 | Kelch-like 29 | 2.027131525 | 0.036831 |
| Bambi | BMP and activin membrane-bound inhibitor | 2.016141198 | 0.044925 |
| Mlec | Malectin | 2.003811198 | 0.022697 |
| Ppp1r9a | Protein phosphatase 1, regulatory (inhibitor) subunit 9A | 1.948922878 | 0.036956 |
| 1810058I24Rik | RIKEN cDNA 1810058I24 gene | 1.899752884 | 0.038628 |
| Osbp2 | Oxysterol binding protein 2 | 1.86993046 | 0.024407 |
| Gm13889 | Predicted gene 13889 | 1.808734268 | 0.036956 |
| Vim | Vimentin | 1.808581233 | 0.041067 |
| Gnai1 | Guanine nucleotide binding protein (G protein), alpha inhibiting 1 | 1.795430532 | 0.036831 |
| Slc1a4 | Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 1.731445442 | 0.042161 |
| Cdc14a | CDC14 cell division cycle 14A | 1.727805031 | 0.041067 |
| Fbl | Fibrillarin | 1.67657139 | 0.045899 |
| Lmo2 | LIM domain only 2 | 1.650427031 | 0.043595 |
| 1110051M20Rik | RIKEN cDNA 1110051M20 gene | 1.601538653 | 0.036831 |
| Cpt1c | Carnitine palmitoyltransferase 1c | 1.577681949 | 0.042456 |
| Fxyd5 | FXYD domain-containing ion transport regulator 5 | 1.552882564 | 0.038628 |
| Lrrc75a | Leucine rich repeat containing 75A | 1.496322239 | 0.046203 |
| Pgap1 | Post-GPI attachment to proteins 1 | 1.490320435 | 0.046282 |
| Zfp36l1 | Zinc finger protein 36, C3H type-like 1 | 1.474391469 | 0.037651 |
| Mir3092 | microRNA 3092 | 1.440648261 | 0.03784 |
| Ppic | Peptidylprolyl isomerase C | 1.435613585 | 0.043595 |
| Ppdpf | Pancreatic progenitor cell differentiation and proliferation factor | 1.336327784 | 0.041067 |
| Cdk4 | Cyclin-dependent kinase 4 | 1.32815528 | 0.037503 |
| St3gal4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 1.281026042 | 0.036831 |
| D630024D03Rik | RIKEN cDNA D630024D03 gene | 1.238041514 | 0.037503 |
| Cdc45 | Cell division cycle 45 | 1.230144783 | 0.022697 |
| Eif4g1 | Eukaryotic translation initiation factor 4, gamma 1 | 1.143713408 | 0.043595 |
| Atp6v1d | ATPase, H+ transporting, lysosomal V1 subunit D | 0.893603982 | 0.048858 |
| Tmx3 | Thioredoxin-related transmembrane protein 3 | 0.84721687 | 0.048858 |
| Olfr1033 | Olfactory receptor 1033 | 0.83993199 | 0.042103 |
| Ergic2 | ERGIC and golgi 2 | 0.834146565 | 0.024407 |
| Aqp1 | Aquaporin 1 | 0.828501756 | 0.046731 |
| Glra2 | Glycine receptor, alpha 2 subunit | 0.817240036 | 0.031256 |
| Gm26744 | Predicted gene, 26744 | 0.810903036 | 0.046282 |
| Spag9 | Sperm associated antigen 9 | 0.802558367 | 0.036831 |
| Rnf115 | Ring finger protein 115 | 0.80194744 | 0.036831 |
| Cd47 | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | 0.800896378 | 0.031314 |
| Dpp4 | Dipeptidylpeptidase 4 | 0.794955116 | 0.041067 |
| Crebl2 | cAMP responsive element binding protein-like 2 | 0.788857661 | 0.022697 |
| Atp6ap2 | ATPase, H+ transporting, lysosomal accessory protein 2 | 0.782409663 | 0.024407 |
| Zfp763 | Zinc finger protein 763 | 0.779090085 | 0.007745 |
| Fez2 | Fasciculation and elongation protein zeta 2 (zygin II) | 0.762992727 | 0.036831 |
| Zfp715 | Zinc finger protein 715 | 0.744750505 | 0.048858 |
| Cyb561d1 | Cytochrome b-561 domain containing 1 | 0.744262296 | 0.048858 |
| Extl2 | Exostoses (multiple)-like 2 | 0.728699546 | 0.048068 |
| Golga7 | Golgi autoantigen, golgin subfamily a, 7 | 0.723018512 | 0.026891 |
| Tgoln1 | Trans-golgi network protein | 0.721857092 | 0.036831 |
| Tpm3 | Tropomyosin 3, gamma | 0.717139012 | 0.044415 |
| Ggh | Gamma-glutamyl hydrolase | 0.714504325 | 0.048882 |
| Scrn3 | Secernin 3 | 0.707136697 | 0.046282 |
| Irak2 | Interleukin-1 receptor-associated kinase 2 | 0.68925238 | 0.037503 |
| Tmem170b | Transmembrane protein 170B | 0.685022667 | 0.046847 |
| Dgke | Diacylglycerol kinase, epsilon | 0.681193453 | 0.024407 |
| Itga1 | Integrin alpha 1 | 0.676125877 | 0.041067 |
| Sdccag8 | Serologically defined colon cancer antigen 8 | 0.662856645 | 0.041067 |
| Hspa12a | Heat shock protein 12A | 0.647460358 | 0.046907 |
| Nceh1 | Neutral cholesterol ester hydrolase 1 | 0.641787883 | 0.042161 |
| Impact | Impact, RWD domain protein | 0.641068766 | 0.022697 |
| Nlrc3 | NLR family, CARD domain containing 3 | 0.616870496 | 0.024407 |
| Pitpnm1 | Phosphatidylinositol transfer protein, membrane-associated 1 | 0.607880798 | 0.024407 |
| Gm19663 | Predicted gene, 19663 | 0.601230962 | 0.035201 |
| Inpp4b | Inositol polyphosphate-4-phosphatase, type II | 0.598629428 | 0.048227 |
| Pde3b | Phosphodiesterase 3B, cGMP-inhibited | 0.586483967 | 0.036956 |
| P2ry10b | Purinergic receptor P2Y, G-protein coupled 10B | 0.58265069 | 0.044415 |
| Ldhb | Lactate dehydrogenase B | 0.575509392 | 0.031256 |
| Smco4 | Single-pass membrane protein with coiled-coil domains 4 | 0.546281346 | 0.039368 |
| Gm14005 | Predicted gene 14005 | 0.545796227 | 0.046282 |
| A630072L19Rik | RIKEN cDNA A630072L19 gene | 0.545449977 | 0.037503 |
| Cyp7b1 | Cytochrome P450, family 7, subfamily b, polypeptide 1 | 0.537648924 | 0.039821 |
| Ldb2 | LIM domain binding 2 | 0.526662693 | 0.036831 |
| Nudt12 | Nudix (nucleoside diphosphate linked moiety X)-type motif 12 | 0.522324687 | 0.037503 |
| Cfh | Complement component factor h | 0.521077661 | 0.036831 |
| Ptpru | Protein tyrosine phosphatase, receptor type, U | 0.517441974 | 0.042879 |
| Pgghg | Protein glucosylgalactosylhydroxylysine glucosidase | 0.479186666 | 0.048882 |
| Acer3 | Alkaline ceramidase 3 | 0.472763137 | 0.036831 |
| Ceacam1 | Carcinoembryonic antigen-related cell adhesion molecule 1 | 0.472603157 | 0.041067 |
| Ccdc88c | Coiled-coil domain containing 88C | 0.469087339 | 0.027307 |
| Fam189a2 | Family with sequence similarity 189, member A2 | 0.467888229 | 0.041067 |
| Cysltr2 | Cysteinyl leukotriene receptor 2 | 0.442737637 | 0.023473 |
| Gramd1c | GRAM domain containing 1C | 0.42091094 | 0.004191 |
| Ntf3 | Neurotrophin 3 | 0.420199255 | 0.038876 |
| Fam174b | Family with sequence similarity 174, member B | 0.414689246 | 0.037572 |
| Slc26a10 | Solute carrier family 26, member 10 | 0.394412144 | 0.022697 |
| Pla2r1 | Phospholipase A2 receptor 1 | 0.354842083 | 0.048858 |
| Gpc1 | Glypican 1 | 0.354767031 | 0.022697 |
| Rnase4 | Ribonuclease, RNase A family 4 | 0.321464634 | 0.043595 |
| Olfm1 | Olfactomedin 1 | 0.276916317 | 0.036956 |
| Cd209b | CD209b antigen | 0.268887021 | 0.009718 |
| Flrt1 | Fibronectin leucine rich transmembrane protein 1 | 0.200652325 | 0.048858 |
| Ada | Adenosine deaminase | 0.153417209 | 0.022697 |
Genes are displayed that were significantly up- or downregulated when compared to Ctnnb1WT controls with Fold change (FC) < 1 or > 1. Adjusted p-values were calculated for the differences of means of log10 of expression values between Ctnnb1OE−EC and Ctnnb1WT.