Table 2.

Overall and clinical variable-stratified comparisons of pS-a-syn-RBC levels between motor subtypes of Parkinson's disease.

Scale	All PD (n = 333)	TD (n = 50)	PIGD (n = 103)	MIX (n = 180)	p (TD vs. PIGD)	p (PIGD vs. MIX)	p (TD vs. MIX)
Sex (male/female)	192/141	20/30	64/39	108/72	0.015	0.800	0.015
Age	60.37 ± 10.35	62.54 ± 11.06	59.48 ± 10.63	60.13 ± 10.73	0.099	0.627	0.162
Age at onset	55.28 ± 11.78	58.13 ± 11.20	54.88 ± 11.34	53.69 ± 14.36	0.149	0.461	0.034
Disease duration, y	5.03 ± 4.48	4.42 ± 3.91	4.60 ± 3.24	5.06 ± 4.68	0.798	0.369	0.332
LEDD, mg/day	367.74 ± 382.04	318.03 ± 374.02	397.64 ± 373.56	371.85 ± 388.92	0.369	0.970	0.356
H and Y stage	2 (2, 3)	2 (2, 3)	2 (2, 3)	2 (1, 3)	0.833	0.628	0.339
pS-α-syn-RBC levels	2.31 ± 0.70	2.19 ± 0.43	2.68 ± 1.11	2.21 ± 0.51	0.001	<0.001	0.855
(raw data, μg/ml)
pS-α-syn-RBC levels	14.17 ± 3.58	13.05 ± 2.64	14.90 ± 5.79	14.56 ± 4.77	0.029	0.573	0.055
(normalized, μg/mg)
pS-α-syn-RBC levels in patients stratified by age at ONSET, ng/mga
<50	14.06 ± 4.82	11.47 ± 1.75	14.25 ± 5.75	14.40 ± 4.49	0.021	0.888	0.017
≥50	14.57 ± 4.92	12.18 ± 2.45	14.89 ± 5.79	14.56 ± 4.77	0.101	0.551	0.191
50–59	14.75 ± 5.44	12.33 ± 2.48	16.48 ± 7.07	14.14 ± 4.84	0.087	0.073	0.669
60–69	14.70 ± 4.53	12.21 ± 2.81	13.68 ± 3.75	15.60 ± 5.07	0.894	0.104	0.149
≥70	13.65 ± 4.21	11.76 ± 1.55	15.07 ± 5.56	12.99 ± 3.89	0.311	0.181	0.959
pS-α-syn-RBC levels in patients stratified by disease duration, ng/mgb
0–2	13.11 ± 4.21	12.61 ± 2.72	13.74 ± 4.58	12.73 ± 4.44	0.588	0.557	0.929
3–5	13.10 ± 4.37	11.92 ± 2.38	13.91 ± 5.51	13.06 ± 3.95	0.176	0.380	0.431
5–10	13.68 ± 5.03	11.06 ± 0.96	13.48 ± 5.83	14.57 ± 4.88	0.411	0.259	0.092
>10	15.58 ± 4.97	12.30 ± 2.46	17.42 ± 6.68	15.68 ± 4.54	0.146	0.120	0.637
pS-α-syn-RBC levels in patients stratified by HandY STAGES, ng/mgc
1	11.44 ± 3.36	10.90 ± 0.92	10.96 ± 3.27	11.84 ± 3.88	0.858	0.647	0.551
2	13.16 ± 4.03	12.01 ± 2.33	12.97 ± 4.39	13.81 ± 4.19	0.508	0.284	0.126
3	14.09 ± 4.95	12.56 ± 2.76	15.01 ± 5.73	14.01 ± 4.86	0.091	0.319	0.256
4–5	16.40 ± 6.76	12.21 ± 2.81	20.87 ± 7.84	15.39 ± 5.25	0.106	0.050	0.307

^a,b,cCovariance analysis adjusting for sex, age, LEDD and disease duration; Bold: p < 0.05. YOPD, Young onset Parkinson's disease; LOPD, Late onset Parkinson's disease; TD, Tremor-dominant subtype; PIGD, postural instability and gait difficulty subtype.