TABLE 4.

Selection of the optimal antipsychotic for a given genotype configuration.

COMT	LPR	D2Taq	Frequency	ARI	CLO	HAL	OLA	PAL	QUE	RIS
MM	LL	A1A1	1.56%	3	10	16	16	14	13	12
MM	LL	A1A2	3.13%	4	12	16	13	15	10	14
MM	LL	A2A2	1.56%	5	12	12	15	13	11	16
MM	Ls	A1A1	3.13%	10	8	17	10	14	15	10
MM	Ls	A1A2	6.25%	5	11	15	13	17	9	14
MM	Ls	A2A2	3.13%	11	9	11	17	14	10	12
MM	ss	A1A1	1.56%	17	12	11	8	11	15	10
MM	ss	A1A2	3.13%	17	18	6	12	9	13	9
MM	ss	A2A2	1.56%	18	15	7	10	12	11	11
MV	LL	A1A1	3.13%	5	14	14	15	13	14	9
MV	LL	A1A2	6.25%	6	14	13	18	13	9	11
MV	LL	A2A2	3.13%	10	14	11	18	11	10	10
MV	Ls	A1A1	6.25%	9	10	15	12	11	14	13
MV	Ls	A1A2	12.50%	7	7	14	14	16	11	15
MV	Ls	A2A2	6.25%	10	9	10	19	12	14	10
MV	ss	A1A1	3.13%	16	15	17	14	7	10	5
MV	ss	A1A2	6.25%	16	16	14	10	8	13	7
MV	ss	A2A2	3.13%	16	13	13	13	10	13	6
VV	LL	A1A1	1.56%	7	10	14	10	19	10	14
VV	LL	A1A2	3.13%	8	8	13	11	17	9	18
VV	LL	A2A2	1.56%	10	10	13	8	15	10	17
VV	Ls	A1A1	3.13%	13	11	14	16	8	14	11
VV	Ls	A1A2	6.25%	12	4	14	11	14	12	18
VV	Ls	A2A2	3.13%	12	9	8	18	11	15	11
VV	ss	A1A1	1.56%	16	14	14	4	11	18	7
VV	ss	A1A2	3.13%	17	17	9	9	9	15	8
VV	ss	A2A2	1.56%	18	13	10	11	11	14	7

For each antipsychotic, individual genotypes are rank ordered for their effects on clinical outcome for efficacy and side-effects. After adding up these rank orders for the three outcomes, one can identify the antipsychotic for each genotype with the lowest rank order and therefore the best overall clinical response. These are shown in yellow. Aripiprazole is the medication that is best for the largest number of genotypes (10) but tied with clozapine for the MV/Ls/A1A2 (the largest group of subjects) and VV/ss/A1A2 combinations. Clozapine and risperidone each are the best choice for six genotypes, Haloperidol and olanzapine for 3 genotypes and quetiapine and paliperidone for one genotype.