Table 1.
Summary of 10 fully vaccinated veterans hospitalized with COVID-19
Patient number | Age (y) | Body Mass Index (kg/m2) | Medical comorbidities | Immune system suppression | Presenting symptoms | Vaccine series received | Days between second vaccine dose and hospitalization | COVID-19 laboratory testing |
Peak supp oxygen need (L/min) | Peak hospital level of care | Status at hospital discharge | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PCR§ status (Ct) | Antigen status║ | Anti-S IgM¶ (nl, 0-0.99) | Anti-N IgG¶ (nl, 0-1.39) | Results interpretation | |||||||||||
1* | 78 | 33 | CHF, cirrhosis, CKD | N | Dyspnea, LE swelling | Pfizer | 66 | Positive (22.4) | Negative | 0.53 | 0.67 | Acute infection | 4 | General | Living |
2* | 71 | 32 | CHF, COPD, DM, IPF | Y‡ | Dyspnea, LE swelling | Pfizer | 63 | Positive (–) | Positive | 0.13 | 0.11 | Acute infection | Mech Vent | ICU | Deceased |
3* | 91 | 32 | Afib, HTN, CVA, AI | N | Cough, N/V/D | Pfizer | 60 | Positive (13.1) | Positive | 0.26 | 0.03 | Acute infection | 6 | General | Living |
4* | 80 | 18 | CHF, Dementia, CVA | N | Weakness, lethargy | Pfizer | 54 | Positive (34.7) | Negative | 0.19 | 0.03 | Acute infection | - | General | Living |
5* | 88 | 41 | COPD, OSA, DM | N | Dyspnea, cough | Moderna | 63 | Positive (13.6) | Positive | 0.14 | 0.03 | Acute infection | 2 | General | Living |
6 | 82 | 19 | COPD, ESRD on HD, HTN | N | Dyspnea, weakness | Moderna | 21 | Positive (32.3) | Negative | 5.79 | 6.23 | Resolving/ Resolved infection | - | ICU | Living |
7*,† | 73 | 26 | CAD, HTN, | N | Fever, bacterial endocarditis | Pfizer | 38 | Positive (37.3) | Negative | 0.87 | 3.55 | Resolving/ Resolved infection | - | General | Living |
8 | 88 | 33 | CAD, DM, CKD | N | Axillary abscess | Moderna | 50 | Positive (44.5) | Negative | 2.62 | 2.20 | Resolving/ Resolved infection | - | General | Living |
9* | 83 | 32 | COPD, DM, CKD | N | COVID-19 positive on SNF testing | Pfizer | 42 | Positive (–) | Positive | 0.28 | 0.52 | Acute infection | - | General | Living |
10* | 78 | 45 | CHF, COPD, DM, CKD | N | Dyspnea, fever | Pfizer | 40 | Positive (19.2) | Positive | 0.94 | 0.02 | Acute infection | 2 | General | Living |
Afib, Atrial fibrillation; AI, Aortic insufficiency; CHF, Congestive heart failure; CKD, Chronic kidney disease; COPD, Chronic obstructive pulmonary disease; Ct, Cycle threshold (if known); CVA, Cerebrovascular accident; DM, Diabetes mellitus; ESRD on HD, End-stage renal disease on hemodialysis; HTN, Hypertension; ICU, intensive care unit; IPF, Idiopathic pulmonary fibrosis; LE, lower extremity; Mech Vent, mechanical ventilation; nl, normal limit; N/V/D, nausea, vomiting, diarrhea; OSA, Obstructive sleep apnea; SNF, skilled nursing facility.
Considered vaccination failure.
Transferred from another acute care hospital.
Receiving nintedanib therapy.
PCR assay (Cepheid, Sunnyvale, CA, bioMerieux. Marcy-l'Étoile, France).
SARS-CoV-2 antigen test (BD Biosciences San Jose, CA).
Serology Anti-S IgM and Anti-N IgG (Abbott Laboratories, Lake Forest, IL).