Table 3.
Analysis of factors independently related to DFS and OS.
| Items | Forward stepwise Cox's proportional hazard regression model | |||
|---|---|---|---|---|
| P value | HR | 95% CI | ||
| Lower | Higher | |||
| DFS | ||||
| Higher baseline EIF3Ba | 0.012 | 1.571 | 1.104 | 2.236 |
| Increased WBC at diagnosisb | 0.008 | 2.966 | 1.321 | 6.659 |
| CR within 4 weeks | <0.001 | 0.095 | 0.037 | 0.248 |
| Allo-HSCT | 0.043 | 0.259 | 0.070 | 0.957 |
| OS | ||||
| Higher baseline EIF3Ba | 0.009 | 1.890 | 1.170 | 3.052 |
| Increased WBC at diagnosisb | 0.009 | 3.644 | 1.387 | 9.576 |
| CR within 4 weeks | <0.001 | 0.087 | 0.030 | 0.254 |
* Baseline EIF3B expression in Ph− ALL patients was categorized as quartile 1 (Q1, 0-25%) = 1, quartile 2 (Q2, 25-50%) = 2, quartile 3 (Q3, 50-75%) = 3 and quartile 4 (Q4, 75-100%) = 4.
# increased WBC was defined as B-ALL patients >30 × 109/L at diagnosis, and T-ALL patients >100 × 109/L at diagnosis. DFS, disease-free survival; OS, overall survival; HR, hazard ratio; CI: confidence interval; EIF3B, eukaryotic translation initiation factor 3 subunit B; CR, complete remission; Allo-HSCT, allogeneic hematopoietic stem cell transplantation.