Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 29;22(4):772–788. doi: 10.1093/biostatistics/kxz065

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by Oxford University Press 2020. This work is written by US Government employees and is in the public domain in the US.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Fig. 2. — Power comparison of global association test with pairwise interactions. Four methods were evaluated, including FTOP with additive structure, MTOP with additive structure (ER fixed), FTOP with pairwise interactions and MTOP with pairwise interactions (ER fixed). For the three figures in the first row, four tumor markers were included in the analysis. Three binary tumor marker and one ordinal tumor marker defined 24 cancer subtypes. Around cases were incomplete. For the three figures in the second row, two extra binary tumor markers were included in the analysis. The six tumor markers defined 96 subtypes. Around cases were incomplete. The total sample size was 25 000, 50 000, and 100 000. We generated random replicates. The power was estimated by controlling the type I error .

Inline graphic — Power comparison of global association test with pairwise interactions. Four methods were evaluated, including FTOP with additive structure, MTOP with additive structure (ER fixed), FTOP with pairwise interactions and MTOP with pairwise interactions (ER fixed). For the three figures in the first row, four tumor markers were included in the analysis. Three binary tumor marker and one ordinal tumor marker defined 24 cancer subtypes. Around cases were incomplete. For the three figures in the second row, two extra binary tumor markers were included in the analysis. The six tumor markers defined 96 subtypes. Around cases were incomplete. The total sample size was 25 000, 50 000, and 100 000. We generated random replicates. The power was estimated by controlling the type I error .