Table 2.

BBB designs factors and Observed responses for PAX-RESV PNPs.

Std	Run	X1	X2	X3	Y1	Y2	Y3
9	1	20	1	0.1	441.3	0.864	31.7
1	2	10	1	0.3	627.1	0.663	22.4
7	3	10	1.5	0.5	841.2	0.751	18.4
11	4	20	1	0.5	383.1	0.334	35.5
6	5	30	1	0.1	102.9	0.192	62.7
12	6	20	2	0.5	537.6	0.384	42.1
3	7	10	2	0.3	945.5	1	12.4
2	8	30	1	0.3	197.2	0.254	59.2
8	9	30	1.5	0.5	228.3	0.253	60.4
16	10	20	1.5	0.3	421.7	0.548	28.7
5	11	10	1.5	0.1	895.5	0.872	17.7
10	12	20	2	0.1	447.4	0.542	22.5
15	13	20	1.5	0.3	411.2	0.457	25.4
13	14	20	1.5	0.3	472.7	0.474	30.4
17	15	20	1.5	0.3	398.7	0.458	34.7
4	16	30	2	0.3	294.7	0.315	48.7
14	17	20	1.5	0.3	421.7	0.548	28.7

X1 = Soluplus (mg·mL⁻¹), X2 = PAX-RESV (mg·mL⁻¹), X3 = TPGS1000 (% w/v), Y1 = Particle size (nm), Y2 = PDI and Y3 = Entrapment Efficiency (%).