Table 4.
Pharmacokinetic parameters following i.v. administration.
| Pharmacokinetic Parameters | Tissue/ Organ |
PAX | PAX PNPs | RESV | RESV PNPs |
|---|---|---|---|---|---|
| Cmax (µg/mL) | Plasma | 88.75 ± 7.98 | 99.42 ± 5.98 | 374.5 ± 6.98 | 399.24 ± 4.18 |
| Tmax (min) | 5 | 5 | 5 | 5 | |
| AUC0–24 (ng/mL) | 324.1 ± 23 | 924.4 ± 79 | 352.7 ± 88 | 1241.5 ± 108 | |
| AUC0–∞ (ng/mL) | 533.8 ± 56 | 1409 ± 74 | 688.7 ± 34 | 286 2 ± 73 | |
| T1/2 (h) | 4.68 | 12.34 | 2.12 | 8.21 | |
| KE (h−1) | 0.21 | 1.42 | 0.12 | 1.47 | |
| MRT(0–t) (h) | 1.24 ± 1.31 | 8.24 ± 3.22 | 0.3 ± 1.7 | 4.8 ± 2.4 |
Cmax: Maximum Concentration; Tmax: Time to reach maximum concentration; AUC Area under curve; T1/2: Half-life; KE: Elimination rate; MRT: Mean residence time.