Table 5.

Diffusion-controlled reservoir and matrix systems.

Diffusion Controlled Reservoir Systems	Diffusion Controlled Monolithic/Matrix Systems
Easier to achieve zero order	Difficult to achieve zero order
Degradable systems may be difficult to design	Suitable for degradable and non-degradable systems
Rupture can result in dose dumping	No danger of dose dumping
Drug inactivation by contact with the polymeric matrix can be avoided	Not all drugs can be blended with a given polymeric matrix