Table II.
Subgroup analyses based on RFA approach, areas in China and single nodule size between RFA and LH
| Subgroup | Categories | Study | Patients | Statistical method | Effect estimate (95% CI) | I2 (%) | P-value |
|---|---|---|---|---|---|---|---|
| Postoperative local recurrence: | |||||||
| Total | 5 | 583 | OR (M-H, Fixed) | 2.71 (1.84–3.99) | 39.0 | < 0.0001 | |
| RFA approach: | |||||||
| LRFA | 1 | 69 | OR (M-H, Fixed) | 1.67 (0.14–19.29) | – | 0.682 | |
| PRFA | 3 | 396 | OR (M-H, Fixed) | 2.05 (1.30–3.23) | 0.0 | 0.002 | |
| Mixed | 1 | 118 | OR (M-H, Fixed) | 6.77 (3.01–15.23) | – | < 0.0001 | |
| Areas: | |||||||
| East | 1 | 118 | OR (M-H, Fixed) | 6.77 (3.01–15.23) | – | < 0.0001 | |
| Mid-west | 4 | 465 | OR (M-H, Fixed) | 2.04 (1.3–3.19) | 0.0 | 0.002 | |
| Overall survival: | |||||||
| Total | 1-y | 7 | 759 | OR (M-H, Fixed) | 0.93 (0.51–1.69) | 0.0 | 0.809 |
| 3-y | 7 | 759 | OR (M-H, Fixed) | 0.62 (0.44–0.87) | 10.0 | 0.006 | |
| Single nodule: | |||||||
| ≤ 5 cm | 1-y | 4 | 479 | OR (M-H, Fixed) | 0.96 (0.40–2.31) | 0.0 | 0.929 |
| 3-y | 4 | 479 | OR (M-H, Fixed) | 0.56 (0.36–0.86) | 41.0 | 0.008 | |
| ≤ 3 cm | 1-y | 3 | 280 | OR (M-H, Fixed) | 0.90 (0.40–2.04) | 0.0 | 0.805 |
| 3-y | 3 | 280 | OR (M-H, Fixed) | 0.73 (0.42–1.29) | 0.0 | 0.278 | |
| RFA approach: | |||||||
| LRFA | 1-y | 1 | 87 | OR (M-H, Fixed) | 1.43 (0.23–9.0) | – | 0.704 |
| 3-y | 1 | 87 | OR (M-H, Fixed) | 0.98 (0.42–2.31) | – | 0.964 | |
| PRFA | 1-y | 5 | 554 | OR (M-H, Fixed) | 0.81 (0.41–1.61) | 0.0 | 0.556 |
| 3-y | 5 | 554 | OR (M-H, Fixed) | 0.58 (0.38–0.87) | 24.0 | 0.009 | |
| Mixed | 1-y | 1 | 118 | OR (M-H, Fixed) | 1.53 (0.25–9.49) | – | 0.649 |
| 3-y | 1 | 118 | OR (M-H, Fixed) | 0.48 (0.18–1.3) | – | 0.146 | |
| Areas: | |||||||
| East | 1-y | 3 | 266 | OR (M-H, Fixed) | 1.02 (0.35–3.02) | 0.0 | 0.966 |
| 3-y | 3 | 266 | OR (M-H, Fixed) | 0.52 (0.3–0.91) | 60.0 | 0.022 | |
| Mid-west | 1-y | 4 | 493 | OR (M-H, Fixed) | 0.89 (0.43–1.83) | 0.0 | 0.750 |
| Disease-free survival: | |||||||
| Total | 1-y | 6 | 662 | OR (M-H, Fixed) | 0.57(0.40–0.83) | 43.0 | 0.003 |
| 3-y | 6 | 662 | OR (M-H, Fixed) | 0.41 (0.30–0.57) | 59.0 | < 0.0001 | |
| Single nodule: | |||||||
| ≤ 5 cm | 1-y | 4 | 479 | OR (M-H, Fixed) | 0.68 (0.44–1.06) | 20.0 | 0.089 |
| 3-y | 4 | 479 | OR (M-H, Fixed) | 0.46 (0.32–0.66) | 31.0 | < 0.0001 | |
| ≤ 3 cm | 1-y | 2 | 183 | OR (M-H, Random) | 0.43 (0.11–1.60) | 70.0 | 0.208 |
| 3-y | 2 | 183 | OR (M-H, Random) | 0.37 (0.07–1.95) | 85.0 | 0.24 | |
| RFA approach: | |||||||
| LRFA | 1-y | 1 | 87 | OR (M-H, Fixed) | 0.91 (0.34–2.48) | – | 0.86 |
| 3-y | 1 | 87 | OR (M-H, Fixed) | 0.85 (0.36–1.99) | – | 0.708 | |
| PRFA | 1-y | 4 | 457 | OR (M-H, Fixed) | 0.67 (0.43–1.05) | 17.0 | 0.08 |
| 3-y | 4 | 457 | OR (M-H, Fixed) | 0.44 (0.31–0.65) | 24.0 | < 0.0001 | |
| Mixed | 1-y | 1 | 118 | OR (M-H, Fixed) | 0.23 (0.09–0.57) | – | 0.002 |
| 3-y | 1 | 118 | OR (M-H, Fixed) | 0.16 (0.07–0.36) | – | < 0.0001 | |
| Areas: | |||||||
| East | 1-y | 3 | 266 | OR (M-H, Fixed) | 0.44 (0.24–0.78) | 51.0 | 0.005 |
| 3-y | 3 | 266 | OR (M-H, Random) | 0.31 (0.11–0.91) | 76.0 | 0.032 | |
| Mid-west | 1-y | 3 | 396 | OR (M-H, Fixed) | 0.69 (0.43–1.12) | 42.0 | 0.133 |
| 3-y | 3 | 396 | OR (M-H, Fixed) | 0.49 (0.33–0.74) | 0.0 | < 0.001 | |
1-y – 1-year, 3-y – 3-year, LRFA – laparoscopic, PRFA – percutaneous, OR – odds ratio, M-H – Mantel-Haenszel method.