Figure 7.

Simulated 3D model of cholesterol-conjugated phytosome docked by phenolic compounds. The phenolic structure is placed within the cholesterol bilayer with a number of hydrogen bindings; (a) overlaid of all compounds interaction with bilayer, (b) catechin; the hydrogen binding occurred between the chroman−3,5,7-triol site and the polar site of phosphatidylcholine (phosphate and choline sites) and the hydroxyl group of cholesterol, and the 1,3-benzenediol site of catechin was adjusted approximately near to the tail, (c) epicatechin; the hydrogen binding occurred between the 1,3-benzenediol site of epicatechin and the polar site of phosphatidylcholine and cholesterol. In addition, the chroman−3,5,7-triol site was adjusted near the tail. (d) Ellagic acid, (e) quercetin, (f) gallic acid.