Table 1.
The results of DEGs and significant gene-modules among groups.
| Groups (matrices) | Total VM+,EMT+ DEGs No. | Up-regulate No. | Down-regulate No. | Total module | Top module-trait⁎⁎ | Total genes of module | Associated gene-disease⁎⁎⁎ | P-value |
|---|---|---|---|---|---|---|---|---|
| Nevi*-Primary (NP) | 3965 | 1805 | 2160 | 22 | Brown | 533 | 113 | 0.0003 |
| Green | 348 | 75 | 0.0015 | |||||
| Lightcyan | 48 | 13 | 0.0351 | |||||
| Nevi-Metastasis (NM) | 6543 | 3237 | 3306 | 24 | Brown | 199 | 40 | 0.0162 |
| Magenta | 75 | 20 | 0.0047 | |||||
| Primary-Metastasis (PM) | 2380 | 1406 | 974 | 18 | Brown | 139 | 33 | 0.0226 |
Abbreviations: VM, vascular mimicry; EMT, epithelial to mesenchymal transition; DEGs, differentially expressed genes.
⁎
Nevi refers to patients diagnosed with any abnormal, congenital formation or mark on the skin or neighbouring mucosa that does not show neoplastic growth.
⁎⁎
Top- module-trait suggested the highest correlation in adjacency matrices according to the dimensionless topological network analysis.
⁎⁎⁎
Associated gene-disease of EMT+ and VM+ genes in each group were determined by applying on DisGeNET online database.