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. 2021 Sep 13;7(10):4798–4808. doi: 10.1021/acsbiomaterials.1c00889

Scheme 1. Overview of the Workflow.

Scheme 1

RGD-PCL-CKFKFQF peptides (15) form amyloid-like fibrils. After cleavage of the RGD-moiety (17), the remaining peptide maintains its amyloid-like fibril morphology (18). Spray-coating of glass-surfaces with amyloid-fibril solution (15) and gradual irradiation with UV-light of the-fibril (15)-coated surface. Direct characterization of the gradual distribution of cleaved RGDG (17) and the precursor-fibril (15) via MALDI-MSI is feasible. A549 cell seeding on the RGD-gradient surface and incubation for 24h leads to a gradual cell distribution.