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. 2021 Sep 28;21(19):6469. doi: 10.3390/s21196469

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Sketch of the gold-coated fibre used to detect HER2 molecules (in red) through SPR, with antibody amplification in a sandwich configuration (in green). Thiolated aptamers are immobilized on the gold surface to target HER2. (b) SPR-dip minimum shift as a function of time in phosphate buffer saline (PBS), HER2 proteins, and PBS after the immersion in HER2 solution. (c) SPR-dip minimum shift as a function of time in PBS, in antibodies (anti-HER2), and in PBS after amplification. Each curve represents one probe per test. Reprinted (adapted) with permission from [92].

(a) Sketch of the gold-coated fibre used to detect HER2 molecules (in red) through SPR, with antibody amplification in a sandwich configuration (in green). Thiolated aptamers are immobilized on the gold surface to target HER2. (b) SPR-dip minimum shift as a function of time in phosphate buffer saline (PBS), HER2 proteins, and PBS after the immersion in HER2 solution. (c) SPR-dip minimum shift as a function of time in PBS, in antibodies (anti-HER2), and in PBS after amplification. Each curve represents one probe per test. Reprinted (adapted) with permission from [92].