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. 2021 Oct 8;26(19):6079. doi: 10.3390/molecules26196079

Figure 5.

Figure 5

Levels of β-arrestin recruitment through OR induced by rubiscolin-5, rubiscolin-6, and opioid compounds. PathHunter® β-arrestin assay was performed in cells expressing MOR (A), DOR (B), and KOR (C) by treating with each compound (10−11–10−5 M). Concentration–response curves were prepared by calculating intracellular β-arrestin levels relative to the data obtained for each positive control: 10−5 M DAMGO for MOR (A), 10−5 M SNC-80 for DOR (B), and 10−6 M of U-50488H for KOR (C). All data points are presented as means ± S.E.M. for three independent experiments (n = 3–6).