Table 1.
Emax and pEC50 values for rubiscolins and opioid compounds obtained in the cAMP assay for MOR, DOR, and KOR.
| MOR | DOR | KOR | ||
|---|---|---|---|---|
| Emax (%) | DAMGO | 100.0 ± 3.0 | 90.9 ± 8.9 | - |
| SNC-80 | 69.8 ± 6.2 * | 100.0 ± 3.6 | 37.7 ± 6.9 + | |
| U-50488H | - | - | 100.0 ± 3.0 | |
| KNT-127 | 115.6 ± 4.3 | 108.4 ± 3.3 | 102.5 ± 9.5 | |
| Rubiscolin-5 | 27.5 ± 5.5 * | 78.4 ± 6.7 # | 9.6 ± 9.0 + | |
| Rubiscolin-6 | 14.3 ± 3.2 * | 103.0 ± 4.1 | 39.8 ± 20.5 + | |
| pEC50 (M) | DAMGO | 8.5 ± 0.1 | 6.2 ± 0.2 # | - |
| SNC-80 | 5.5 ± 0.1 * | 9.4 ± 0.1 | 5.6 ± 0.3 + | |
| U-50488H | - | - | 9.1 ± 0.1 | |
| KNT-127 | 7.2 ± 0.1 * | 10.0 ± 0.2 | 6.5 ± 0.2 | |
| Rubiscolin-5 | n.d. | 6.3 ± 0.2 # | n.d. | |
| Rubiscolin-6 | n.d. | 6.5 ± 0.1 # | n.d. | |
Emax (means ± S.E.M.) and pEC50 (-LogEC50, means ± S.E.M.) were calculated according to the results shown in Figure 4. * p < 0.05 versus DAMGO, # p < 0.05 versus SNC-80, + p < 0.05 versus U-50488H. n.d.; not detected.