Table 2.
Emax and pEC50 values for rubiscolins and opioid compounds obtained in the cAMP assay for MOR, DOR, and MOR/DOR.
| MOR | DOR | MOR/DOR | ||
|---|---|---|---|---|
| Emax (%) | DAMGO | 100.0 ± 3.0 | 90.9 ± 8.9 | 91.1 ± 5.4 |
| SNC-80 | 69.8 ± 6.2 * | 100.0 ± 3.6 | 71.4 ± 3.7 + | |
| ML335 | 112.5 ± 5.3 | 111.6 ± 3.6 | 100.0 ± 4.2 | |
| KNT-127 | 115.6 ± 4.3 | 108.4 ± 3.3 | 92.1 ± 2.4 | |
| Rubiscolin-5 | 27.5 ± 5.5 * | 78.4 ± 6.7 # | 45.8 ± 6.3 + | |
| Rubiscolin-6 | 14.3 ± 3.2 * | 103.0 ± 4.1 | 60.6 ± 6.3 + | |
| pEC50 (M) | DAMGO | 8.5 ± 0.1 | 6.2 ± 0.2 # | 7.2 ± 0.2 |
| SNC-80 | 5.5 ± 0.1 * | 9.4 ± 0.1 | 8.6 ± 0.2 + | |
| ML335 | 7.6 ± 0.1 * | 7.5 ± 0.1 # | 7.0 ± 0.1 | |
| KNT-127 | 7.2 ± 0.1 * | 10.0 ± 0.2 | 9.5 ± 0.1 + | |
| Rubiscolin-5 | n.d. | 6.3 ± 0.2 # | 6.4 ± 0.3 | |
| Rubiscolin-6 | n.d. | 6.5 ± 0.1 # | 6.4 ± 0.2 | |
Emax (means ± S.E.M.) and pEC50 (-LogEC50, means ± S.E.M.) were calculated according to the results shown in Figure 6. * p < 0.05 versus DAMGO, # p < 0.05 versus SNC-80, + p < 0.05 versus ML335. n.d.; not detected.