Figure 3.

Accumulation of Lipofuscin in hippocampal pyramidal neurons during aging is not altered by CB2 deletion. Representative microscopy images of Lipofuscin accumulation in hippocampal pyramidal neurons with a scale bar of 50 μm (A). The area covered with lipofuscin (B) and the particle density (C) show a significant increase but is not different between WT and CB₂R^−/− mice. WT mice—white circle; CB₂R^−/− mice—grey circles. N = 6 mice/genotype/age group, two substacks per animal. Each point represents a single substack. Red line indicates the mean value ± SEM. Two-way ANOVA.