Table 2.
Baseline and effect of treatment on FBG, 2HPG and HbA1c
| Study (author year) |
Drug | FBG | 2HPG | HbA1c | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (SD) | After treatment (SD) | Change from baseline (SD) | Baseline (SD) | After treatment (SD) | Change from baseline (SD) | Baseline (SD) | After treatment (SD) | Change from baseline (SD) | ||
| Rowan 2008 | Metformin | 102.6 (21.6) | 93.6 (10.8) | −9 (18.7) | 174.6 (37.8) | 111.6 (10.8) | −63 (33.72) | 5.7 (0.6) | 5.6 (0.5) | −0.1 (0.557) |
| Insulin | 102.6 (19.8) | 91.8 (12.6) | −10.8 (17.36) | 169.2 (37.8) | 115.2 (16.2) | −54 (32.85) | 5.8 (0.7) | 5.7 (0.6) | −0.1 (0.656) | |
| Niromanesh 2012 | Metformin | 104.7 (8.6) | 88.3 (7.7) | −16.4 (8.19) | 164.6 (28.6) | 111.3 (9.1) | −53.3 (25.31) | 5.7 (0.6) | 4.3 (0.5) | −1.4 (0.56) |
| Insulin | 107.1 (9.2) | 88.7 (6.3) | −18.4 (8.15) | 172.5 (30) | 111.1 (9) | −61.4 (26.66) | 5.6 (0.7) | 4.3 (0.4) | −1.3 (0.61) | |
| Hassan 2012 | Metformin | 100.89 | NA | NA | 231.56 | NA | NA | 5.4 (0.47) | 5.7 (0.47) | 0.3 (0.47) |
| Insulin | 102.11 | NA | NA | 236.41 | NA | NA | 5.19 (0.59) | 5.37 (0.48) | 0.18 (0.543) | |
| Spaulonei 2013 | Metformin | 102.15 (21.96) | 90.09 (16.29) | −12.06 (19.75) | 124.17 (24.4) | 108.44 (13.39) | −15.73 (21.16) | 5.9 (0.75) | NA | NA |
| Insulin | 100.87 (15.05) | 88.35 (7.45) | −12.52 (13.03) | 125.39 (22.12) | 112.32 (13.69) | −13.07 (19.34) | 5.93 (0.8) | NA | NA | |
| Tertti 2013 | Metformin | 99 (9) | NA | NA | 149.4 (32.4) | NA | NA | 5.48 (0.34) | 5.68 (0.33) | 0.2 (0.34) |
| Insulin | 100.8 (7.2) | NA | NA | 142.2 (30.6) | NA | NA | 5.51 (0.34) | 5.69 (0.36) | 0.18 (0.35) | |
| Ashoush 2016 | Metformin | 105.7 (4.7) | 78 (3.1) | −27.7 (4.14) | 175.7 (10) | 109.9 (3.7) | −65.8 (8.757) | 5.7 (0.5) | NA | NA |
| Insulin | 106.4 (4.4) | 79.9 (3.7) | −26.5 (4.1) | 177.6 (8.8) | 111.3 (4.2) | −66.3 (7.624) | 5.8 (0.6) | NA | NA | |
| Saleh 2016 | Metformin | 136.09 (39.85) | 93.23 (13.7) | −42.86 (35.07) | 198.32 (214.67) | 116.52 (3.53) | −81.8 (212.927) | NA | NA | NA |
| Insulin | 137.56 (41.1) | 94.33 (11.11) | −43.23 (36.82) | 196.52 (15.45) | 117.12 (3.45) | −79.4 (14.05) | NA | NA | NA | |
| Arshad 2017 | Metformin | 104.4 (13.12)* | 93.48 (11.9) | −10.92 (12.55) | NA | NA | NA | 5.28 (0.42) | 5.42 (0.346) | 0.14 (0.388) |
| Insulin | 117.9 (29.06)* | 102.08 (20.63) | −15.82 (25.9) | NA | NA | NA | 5.43 (0.34) | 5.72 (0.35) | 0.29 (0.345) | |
| Gamal 2018 | Metformin | NA | NA | NA | NA | NA | NA | 6.9 (0.4) | 6.5 (0.4) | −0.4 (0.4) |
| Insulin | NA | NA | NA | NA | NA | NA | 6.7 (0.5) | 6.4 (0.4) | −0.3 (0.46) | |
| Wasim 2019 | Metformin | 117 (18.1) | 92.1 (6) | −24.9 (15.97) | NA | NA | NA | 6.99 (7.5) | 6 (0.9) | − 0.99 (7.09) |
| Insulin | 120 (22.4) | 96.6 (6.2) | −23.4 (20.03) | NA | NA | NA | 7.1 (0.79) | 6.1 (1.1) | −1 (0.98) | |
| Langer 2000 | Glyburide | 104 (25) | 98 (13) | −6 (21.7) | 174 (31) | 113 (22) | −61 (27.6) | 5.7 (1.3) | 5.5 (0.7) | −0.2 (1.13) |
| Insulin | 108 (26) | 98 (16) | −10 (22.7) | 174 (39) | 112 (15) | −62 (34.1) | 5.6 (1.2) | 5.4 (0.6) | −0.2 (1.04) | |
| Anjalakshi 2007 | Glyburide | NA | NA | NA | 167.1 (22.97) | 95.29 (7.41) | −71.81 (20.31) | 5.48 (0.79) | 5.3 (0.34) | −0.18 (0.686) |
| Insulin | NA | NA | NA | 174.92 (31.05) | 93 (9.75) | −81.92 (27.5) | 5.75 (1.23) | 5.5 (0.62) | −0.25 (1.065) | |
| Lain 2009 | Glyburide | 100.9 (15.9) | 90.4 (21.8) | −10.5 (19.53) | 176.9 (35.9) | 109.8 (21.8) | −67.1 (31.33) | 5 (0.5) | NA | NA |
| Insulin | 101.5 (12.4) | 90.9 (7) | −10.6 (10.77) | 173.1 (34.9) | 106 (14) | −67.1 (30.42) | 5 (0.5) | NA | NA | |
| Mukhopadhyay 2012 | Glyburide | 103.5 (14.62) | 88.23 (6.55) | −15.27 (12.68) | 184.1 (20.46)* | 122.7 (10.3) | −61.4 (17.72) | 6.25 (0.6) | 6.46 (0.77) | −0.17 (0.577) |
| Insulin | 109.3 (19.63) | 88.17 (8.44) | −21.13 (17.06) | 194.3 (18.47)* | 128 (12.38) | −66.3 (16.3) | 6.46 (0.77) | 6.24 (0.57) | −0.22 (0.692) | |
| Mirzamoradi 2015 | Glyburide | 109.83 (68.99) | 114.02 (10.65) | 4.19 (64.33) | NA | 115.46 (8.21) | NA | NA | NA | NA |
| Insulin | 112.15 (19.39) | 123.42 (14.71) | 11.27 (17.53) | NA | 120.15 (9.56) | NA | NA | NA | NA | |
| Silva 2012 | Glyburide | 94.04 (16.25) | 88.23 (11.71) | −5.81 (14.52) | 160.83 (18.6) | 126.44 (16.91) | −34.39 (17.81) | NA | 5.62 (0.85) | NA |
| Metformin | 95.84 (20.91) | 90.52 (11.78) | −5.32 (18.16) | 165.59 (21.9) | 126.48 (20.51) | −39.11 (21.18) | NA | 5.51 (0.78) | NA | |
| George 2015 | Glyburide | 100.8 (14.4) | 86.4 (24.4) | −14.4 (21.24) | 181.8 (45) | 119.4 (21.25) | −62.4 (38.99) | 5.9 (0.5) | NA | NA |
| Metformin | 102.6 (14.4) | 88.2 (10.8) | −14.4 (12.98) | 194.4 (46.8) | 123.6 (15.41) | −70.8 (41.31) | 5.8 (0.6) | NA | NA | |
| Nachum 2017 | Glyburide | 95.9 (10.4) | 88.7 (10.2) | −7.2 (10.3) | 127.6 (19.1) | 115.3 (13.8) | −12.3 (17.08) | NA | NA | NA |
| Metformin | 96.8 (10.5) | 91.3 (8.8) | −5.5 (9.76) | 125.4 (12.8) | 112.6 (12.3) | −12.8 (12.56) | NA | NA | NA | |
FBG fasting blood glucose, 2HPG 2-h postprandial blood glucose, HbA1c hemoglobin A1c, SD standard deviation
* P value < 0.05, marked in bold