Table 5.
The association analysis stratified for tumor location
| Location | Model | Genotype | Control (%) | Case (%) | OR (95%CI) | P-value | ORa | P-valuea |
|---|---|---|---|---|---|---|---|---|
| Colon | Codominant | C/C | 305 (61%) | 105 (51%) | Ref | 2.17e−05 | Ref | 5.30e−05 |
| C/T | 161 (32.2%) | 62 (30.1%) | 1.12 (0.77–1.62) | 1.1 (0.76–1.6) | ||||
| T/T | 34 (6.8%) | 39 (18.9%) | 3.33 (2–5.55) | 3.27 (1.93–5.54) | ||||
| Dominant | C/C | 305 (61%) | 105 (51%) | Ref | 0.014404 | Ref | 0.021843 | |
| C/T–T/T | 195 (39%) | 101 (49%) | 1.5 (1.08–2.09) | 1.48 (1.06–2.07) | ||||
| Recessive | C/C–C/T | 466 (93.2%) | 167 (81.1%) | Ref | 4.31e−06 | Ref | 1.04e−05 | |
| T/T | 34 (6.8%) | 39 (18.9%) | 3.2 (1.96–5.24) | 3.16 (1.9–5.26) | ||||
| Over dominant | C/C–T/T | 339 (67.8%) | 144 (69.9%) | Ref | 0.583813 | Ref | 0.558616 | |
| C/T | 161 (32.2%) | 62 (30.1%) | 0.91 (0.64–1.29) | 0.9 (0.63–1.29) | ||||
| log-Additive | 0, 1, 2 | 500 (70.8%) | 206 (29.2%) | 1.6 (1.26–2.02) | 9.44e−05 | 1.57 (1.24–2) | 0.000217 | |
| Rectosigmoid | Codominant | C/C | 305 (61%) | 110 (51.6%) | Ref | 7.24e−10 | Ref | 5.88e−09 |
| C/T | 161 (32.2%) | 50 (23.5%) | 0.86 (0.59–1.27) | 0.79 (0.53–1.18) | ||||
| T/T | 34 (6.8%) | 53 (24.9%) | 4.32 (2.67–7) | 4.16 (2.48–6.96) | ||||
| Dominant | C/C | 305 (61%) | 110 (51.6%) | Ref | 0.020807 | Ref | 0.080438 | |
| C/T–T/T | 195 (39%) | 103 (48.4%) | 1.46 (1.06–2.02) | 1.35 (0.96–1.9) | ||||
| Recessive | C/C–C/T | 466 (93.2%) | 160 (75.1%) | Ref | 1.17e−10 | Ref | 1.49e−09 | |
| T/T | 34 (6.8%) | 53 (24.9%) | 4.54 (2.85–7.24) | 4.5 (2.73–7.41) | ||||
| Over dominant | C/C–T/T | 339 (67.8%) | 163 (76.5%) | Ref | 0.017874 | Ref | 0.006936 | |
| C/T | 161 (32.2%) | 50 (23.5%) | 0.65 (0.45–0.93) | 0.59 (0.4–0.87) | ||||
| log-Additive | 0, 1, 2 | 500 (70.1%) | 213 (29.9%) | 1.71 (1.37–2.14) | 2.54e−06 | 1.64 (1.29–2.07) | 3.75e−05 |
Bold indicates a p-value less than 0.05 is statistically significant
aAdjusted for age, sex, and addiction