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. 2021 Oct 13;13:47. doi: 10.1186/s11689-021-09394-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — JZL-184 treatment improves inter-trial phase coherence to auditory chirp in Fmr1 KO mice 4 h post-treatment. Graphs show group mean differences between JZL-184-treated Fmr1 KO mice (N = 13) 4 h post-treatment compared with Fmr1 KO mice prior to treatment (N = 22) in left/right frontal, medial, and temporal regions of the mouse cortex. Monte Carlo statistical method on cluster analysis revealed a significant increase (p < 0.025) in average ITPC values in JZL-184-treated Fmr1 KO mice (yellow and red regions with dotted black outline) in the gamma-band range (~ 30–100 Hz) in all regions. Abbreviations: LF, left frontal; RF, right frontal; LM, left medial; RM, right medial; LT, left temporal; RT, right temporal