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. 2021 Oct 13;21:1062. doi: 10.1186/s12879-021-06748-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Heatmap of KEGG function difference between groups. Each function was compared between groups, one enriched was marker 1, and the most enriched was 3, the range is from 0 to 3. Cluster C1 and Cluster C2 were inclined Group H and A Cluster C3 and Cluster C4 were inclined Group M and S. Such as bacterial secretion system and Pathogenicity were enriched in HFMD case