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Effects of GPR39 and PGC-1α CRISPR, and SIRT1 inhibitor EX527 with TC-G 1008 on immunofluorescence staining of MPO and IL-1β at 48-h post-HIE. TC-G 1008 treatment or TC-G 1008 with DMSO significantly reduced the number of IL-1β/MPO-positive cells, which were abolished by either GPR39 CRISPR or PGC-1α CRISPR, or EX527. *p < 0.05 vs. sham; #p < 0.05 vs. HIE + vehicle; @p < 0.05 vs. HIE + TC-G1008 + control CRISPR; $p < 0.05 vs. HIE + TC-G1008 + DMSO. n = 4 for each group
