Fig. 5.
Combination of pCr and TIMP2 IGFBP7 for the early detection of CS-AKI. Legend: CS-AKI: Cardiac surgery-associated acute kidney injury; CPB: cardiopulmonary bypass; ∆pCrpostCPB-H6: change in plasma creatinine from CPB to H6; TIMP2 IGFBP7: tissue inhibitor of metalloproteinase 2 – insulin-like growth factor-binding protein 7. CS-AKI was classified according to Kidney Disease Improving Global Outcome (KDIGO) guidelines. For each panel, the marked overlap between values TIMP2 IGFBP7 in patients who developed CS-AKI and those who did not suggests that TIMP2 IGFBP7 at H6 was of no evident added value to ∆pCrpostCPB-H6 for a better stratification of the risk of CS-AKI as compared with the use of ∆pCrpostCPB-H6 alone