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. 2021 Oct 13;18:228. doi: 10.1186/s12974-021-02287-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Senescent CD8⁺ lymphocytes in CMV-positive versus CMV-negative patients and controls. A Two-way ANOVA with Sidak’s multiple comparisons test showed a statistically significant main effect of CMV seropositivity, F(1,118) = 11.9, p < 0.001. Post hoc pairwise comparison revealed a significant increase in the absolute count of CD8⁺ CD28^loCD57^hi T lymphocytes in CMV-positive compared to CMV-negative controls (p = 0.026). There was no statistically significant difference between CMV-positive and CMV-negative PD patients (p = 0.260). B Two-way ANOVA with Sidak's multiple comparisons test showed a statistically significant main effect of CMV seropositivity F(1,118) = 26.16, p < 0.0001 and main effect of group F(1,118) = 7.382, p = 0.008. Post hoc pairwise comparison revealed a significant increase in the absolute count of CD8⁺ TEMRA cells in CMV-positive compared to CMV-negative controls (p < 0.001) and in CMV-positive compared to CMV-negative PD patients (p = 0.026) CMV: Cytomegalovirus, TEMRA: terminally differentiated effector memory cells re-expressing CD45RA. ***p < 0.001,*p < 0.05