Table 3.
CD4+ and CD8+ T lymphocyte subsets
| % of total lymphocytes | Absolute cell count—cells × 109/L | |||||
|---|---|---|---|---|---|---|
| Control | PD | p | Control | PD | p | |
| CD4+ | ||||||
| Naïve | 24.9 (14.4) | 28.2 (14.6) | 0.210 | 0.388 (0.282) | 0.374 (0.183) | 0.761 |
| Central memory | 14.4 (7.3) | 15.1 (7.5) | 0.624 | 0.217 (0.115) | 0.214 (0.125) | 0.899 |
| Effector memory | 6.0 (4.0) | 5.7 (3.7) | 0.656 | 0.095 (0.069) | 0.082 (0.069) | 0.332 |
| TEMRA | 2.1 (3.5) | 1.9 (2.4) | 0.734 | 0.037 (0.072) | 0.025 (0.032) | 0.246 |
| CD8+ | ||||||
| Naïve | 5.3 (2.7) | 5.9 (3.2) | 0.313 | 0.080 (0.040) | 0.081 (0.050) | 0.967 |
| Central memory | 2.2 (2.1) | 1.9 (1.3) | 0.277 | 0.033 (0.033) | 0.027 (0.021) | 0.205 |
| Effector memory | 3.6 (3.7) | 2.9 (3.6) | 0.223 | 0.058 (0.068) | 0.043 (0.041) | 0.131 |
| TEMRA | 12.6 (9.7) | 10.2 (7.0) | 0.121 | 0.213 (0.221) | 0.140 (0.100) | 0.019* |
| CD28loCD57hi | 5.9 (6.5) | 4.9 (4.5) | 0.327 | 0.100 (0.145) | 0.066 (0.061) | 0.087 |
TEMRA, terminally differentiated effector memory cells re-expressing CD45RA. Comparisons were done using two-tailed unpaired t-tests. The values represent the mean (SD); *p < 0.05. Significant values are in italics