Table 1.

mRNA COVID-19 Vaccine Candidates in Development: Current Stability Profile, Dose, and Dosing Schedule (Status March 22, 2021).

Sponsor	Stability in Frozen State	Stability at 2 °C–8 °C	Stability at Room Temperature	Dose (Injection Volume); Dosing Schedule	References
Pfizer-BioNTech	−80 °C to −60 °C, up to 6 months	Up to 5 days	Up to 2 h (up to 6 h after dilution)	100 mg (0.5 mL); day 1, day 29	(Moderna announces longer shelf life for its COVID-19 vaccine candidate at refrigerated temperatures. https://www.businesswire.com/news/home/202 0, 2021, A study to evaluate efficacy, safety, and immunogenicity of mRNA-, 2021)
Moderna	−20 °C, up to 6 months	30 days	Up to 12 h	30 mg (0.3 mL); day 1, day 21	(The cold truth about COVID-19 vaccines. https://www.genengnews.com/news/ the-cold-truth-about-covid-19-vaccines/. Accessed March 22, 2021, A phase 1/2/3, placebo-controlled, randomized, observer-blind, dose-finding study to evaluate the safety, tolerability, immunogenicity, and efficacy of SARS- CoV-2 RNA vaccine candidates against COVID-19 in healthy individuals, 2021, Information for healthcare professionals on pfizer BioNTech COVID-19 vaccine, 2021)
CureVac	− 60 °C, at least 3 months	At least 3 months	Up to 24 h	12 mg (no information); day 1, day 29	(A dose-confirmation study to evaluate the safety, reactogenicity and immu- nogenicity of vaccine CVnCoV in healthy adults for COVID-19, 2021, CureVac says its COVID-19 vaccine can be stored at standard refrigerator temperature, 2021, CureVac's COVID-19 vaccine candidate, CVnCoV, suitable for standard fridge temperature logistics, 2021)