Table 1.

Properties of MM TG neuronal groups

Gr1	Marker	N	Size; μm2	RMP; mV	dB; ms	Shape3	AHP80; ms	AHP peak4	AP Thr.; pA	AP train; Hz	ATP	5HT; pA	Tau; ms	Shape Curr5
S1	IB4 Nav1.8	16	20.5 ± 0.8	−40.4 ± 2.1	11.9 ± 1.1	Bow	35.2 ± 4.9	−14.5 ± 1.2	405 ± 177	10 ± 2.2	0	0	19.2 ± 6.5	Smooth
S2	IB4 Nav1.8	52	19.9 ± 0.4	−41.3 ± 1.0	11.5 ± 0.6	Deflection	67.9 ± 4.0	−19.0 ± 0.8	156.6 ± 20.3	8.3 ± 0.8	0	0	26.3 ± 4.2	Smooth6,7
S3	trpV1 CGRP Nav1.8	47	21.4 ± 0.4	−44.7 ± 1.0	8.7 ± 0.3	Hump	76.3 ± 17.2	−13.7 ± 0.9	109.1 ± 23.4	11.8 ± 2.2	0	0	20.6 ± 2.6	Smooth7
S4	trpV1 CGRP Nav1.8	24	21.4 ± 0.9	−43.0 ± 1.1	8.5 ± 0.5	Deflection	63.5 ± 20.5	−10.3 ± 1.4	64.3 ± 14.3	6.3 ± 1.3	0	0	16.9 ± 2.1	Smooth6
S5	CGRP 5HT3a trkC	30	21.5 ± 1.0	−44.7 ± 1.5	7.7 ± 0.5	Straight	65.2 ± 16.7	−13.7 ± 1.3	50.0 ± 0	22 ± 3.8	0	195 ± 18	24 ± 4.6	Box like6
M1	CGRP 5HT3a	34	29.5 ± 0.9	−52.1 ± 1.1	6.3 ± 0.2	Deflection	92.4 ± 11.7	−13.2 ± 1.2	316 ± 107	10 ± 3.7	0	818 ± 100	3.5 ± 0.6	Box like6
M29	CGRP 5HT3a8 trkC PV	66	30.7 ± 0.5	−51.6 ± 1.6	4.8 ± 0.2	Straight	73.6 ± 9.1	−13.3 ± 0.5	580 ± 128	13.1 ± 3.3	0	774 ± 88	22.0 ± 2.3	Spike
M3	trkC PV	56	33.5 ± 0.6	−55.2 ± 0.6	2.8 ± 0.1	Straight	86.3 ± 12.0	−10.3 ± 0.6	1280 ± 152	7 ± 2.3	0	011	22.3 ± 1.9	Spike10
M4	trkC PV	40	30.5 ± 0.8	−54.0 ± 0.7	1.9 ± 0.06	Straight	6.9 ± 0.6	−10.7 ± 0.8	0	0	0	0	16.0 ± 2.7	Box like

¹Green font is non-peptiderigic; red font is peptidergic, and blue font is mechanoreceptors.

²Size in μm is calculated from pF (see Materials and Methods).

³Characteristic feature on AP downstroke: bow, hump, deflection, and straight (Figs. 1B,C, 2A).

⁴AHP₈₀ peak is a lowest point of AP, and it is measured in negative mV.

⁵Characteristic feature of the last (generated by stepping to +20 mV) outward current: “smooth,” “box like,” and “spike” (Figs. 1E, 2D,E, 3E,F, 4C,D).

⁶Currents do not have inward component.

⁷Neurons are responsive to MO.

⁸5HT3a is encoded by Htr3a gene.

⁹Contain low level Nav1.8.

¹⁰Spike is sharper in M3 than M2.

¹¹Some (≈15%) M3 neurons respond to 5HT (30 μm).