Table 4.
Prognostic factors identified by multivariate analysis.
| Clinicopathologic parameters | iCCA | pCCA | dCCA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | P* | HR | 95%CI | P* | HR | 95%CI | P* | ||
| Age (years) |
<60 | 1 | 1 | 1 | ||||||
| ≥60 | 1.34 | 0.69–2.57 | 0.387 | 1.98 | 0.82–4.75 | 0.129 | 0.83 | 0.17–3.93 | 0.810 | |
| Sex | Male | 1 | 1 | 1 | ||||||
| Female | 0.84 | 0.45–1.62 | 0.575 | 0.85 | 0.36–1.99 | 0.702 | 0.59 | 0.17–2.10 | 0.415 | |
| Differentiation | Well | 1 | 1 | 1 | ||||||
| Moderately+Poorly | 0.89 | 0.40–1.99 | 0.773 | 1.98 | 0.87–4.50 | 0.103 | 1.16 | 0.36–3.77 | 0.802 | |
| Size# | <3/5 cm | 1 | 1 | 1 | ||||||
| ≥3/5 cm | 1.76 | 0.89–3.48 | 0.107 | 1.29 | 0.60–2.74 | 0.516 | 0.49 | 0.09–2.55 | 0.397 | |
| T stage | T1 + T2 | 1 | 1 | 1 | ||||||
| T3 + T4 | 0.83 | 0.40–1.71 | 0.604 | 2.15 | 0.99–4.71 | 0.057 | 1.60 | 0.45–5.72 | 0.467 | |
| N stage | N0 | 1 | 1 | 1 | ||||||
| N1 + 2 | 1.66 | 0.81–3.40 | 0.167 | 2.67 | 1.14–6.23 | 0.023 | 0.37 | 0.06–2.12 | 0.262 | |
| M stage | M0 | 1 | 1 | |||||||
| M1 | 2.63 | 0.78–8.78 | 0.117 | 5.44 | 1.02–28.96 | 0.047 | ||||
| DUSP11 | Low | 1 | 1 | 1 | ||||||
| High | 2.33 | 1.13–4.83 | 0.022 | 1.01 | 0.47–2.13 | 0.993 | 1.31 | 0.42–4.17 | 0.643 | |
*Cox-regression model.
#represents 5 cm for iCCA and 3 cm for pCCA/dCCA.