Figure 4.

Prebronchodilator percent predicted FEV₁ (FEV₁PP) by sex hormone levels in SARP (Severe Asthma Research Program) I, II, and III adult participants. (A) In women enrolled in SARP I, II, and III, the FEV₁PP correlated positively with dehydroepiandrosterone sulfate (DHEA-S) (R² = 0.156; <2.2 × 10⁻¹⁶) but not with free testosterone (P = 0.15). (B) In adult men, the FEV₁PP correlated positively with DHEA-S (R² = 0.158; P = 1.5 × 10⁻¹⁰) and testosterone (R² = 0.034; P = 0.004). The gray shaded regions represent SEs.