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Treatment of NCI-H295R and SW13 with KU758 decreases aggregate formation in a dose dependent manner with near total inhibition at doses of both 1.0 μM and 2.0 μM KU758 in SW13 and NCI-H295R cells. Aggregate formation after treatment of ACC cells with 1.0 μM 17-AAG is shown for comparison. ACC, adrenocortical carcinoma.
