Treatment of NCI-H295R cells with KU758 causes statistically significant (greater than 2-fold, P < .05) upregulation of the lncRNAs ADAMTS9-AS2, CAHM, GAS5, RMST, ZFAS1, BCAR4, SPRY4-IT1, CBR3-AS1, HIF1A-AS1, HULC, LINC00887, and LUCAT1. Treatment with 17-AAG is associated with statistically significant upregulation of BCAR4 and BLACAT1 and downregulation of GACAT1, LINC00261, TSIX, and LSINCT5. Treatment of NCI-H295R cells with Hsp90 inhibition results in upregulation of MEG3, DLX6-AS1, H19, GAS5, HOTAIRM1, and MALAT1. Oncogenes are denoted in orange and tumor suppressors are denoted in blue. (Color version of figure is available online.)