Comparison 1. Atherectomy versus balloon angioplasty.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 6‐month primary patency	3	186	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.94, 1.20]
1.1.1 Balloon angioplasty	2	101	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.51, 1.81]
1.1.2 Drug‐eluting balloon angioplasty	1	85	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.94, 1.21]
1.2 12‐month primary patency	2	149	Risk Ratio (M‐H, Random, 95% CI)	1.20 [0.78, 1.84]
1.2.1 Balloon angioplasty	1	62	Risk Ratio (M‐H, Random, 95% CI)	1.55 [0.90, 2.67]
1.2.2 Drug‐eluting balloon angioplasty	1	87	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.86, 1.26]
1.3 Mortality	3	210	Risk Ratio (M‐H, Random, 95% CI)	0.50 [0.10, 2.66]
1.3.1 Balloon angioplasty	2	108	Risk Ratio (M‐H, Random, 95% CI)	0.27 [0.04, 1.68]
1.3.2 Drug‐eluting balloon angioplasty	1	102	Risk Ratio (M‐H, Random, 95% CI)	2.25 [0.21, 24.04]
1.4 Initial technical failure rates	6	425	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.22, 1.08]
1.4.1 Balloon angioplasty	5	324	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.20, 1.73]
1.4.2 Drug‐eluting balloon angioplasty	1	101	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.12, 0.72]
1.5 Bailout stenting	4	315	Risk Ratio (M‐H, Random, 95% CI)	0.26 [0.09, 0.74]
1.5.1 Balloon angioplasty	3	213	Risk Ratio (M‐H, Random, 95% CI)	0.26 [0.07, 0.89]
1.5.2 Drug‐eluting balloon angioplasty	1	102	Risk Ratio (M‐H, Random, 95% CI)	0.22 [0.01, 4.56]
1.6 Balloon inflation pressure	3	213	Mean Difference (IV, Random, 95% CI)	‐3.68 [‐5.36, ‐2.01]
1.7 Target vessel revascularisation at 6 months	2	136	Risk Ratio (M‐H, Random, 95% CI)	0.51 [0.06, 4.42]
1.7.1 Balloon angioplasty	1	42	Risk Ratio (M‐H, Random, 95% CI)	0.13 [0.01, 2.38]
1.7.2 Drug‐eluting balloon angioplasty	1	94	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.17, 8.07]
1.8 Target vessel revascularisation at 12 months	3	176	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.25, 1.42]
1.8.1 Balloon angioplasty	2	85	Risk Ratio (M‐H, Random, 95% CI)	0.46 [0.15, 1.39]
1.8.2 Drug‐eluting balloon angioplasty	1	91	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.22, 3.86]
1.9 Complication rate	6	387	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.28, 1.68]
1.9.1 Balloon angioplasty	5	285	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.22, 2.42]
1.9.2 Drug‐eluting balloon angioplasty	1	102	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.27, 1.72]
1.10 Embolisation	6	387	Risk Ratio (M‐H, Random, 95% CI)	2.51 [0.64, 9.80]
1.10.1 Plain balloon angioplasty	5	285	Risk Ratio (M‐H, Random, 95% CI)	1.84 [0.39, 8.55]
1.10.2 Drug‐eluting balloon angioplasty	1	102	Risk Ratio (M‐H, Random, 95% CI)	7.86 [0.42, 148.34]
1.11 Dissections	4	290	Risk Ratio (M‐H, Random, 95% CI)	0.28 [0.14, 0.54]
1.11.1 Plain balloon angioplasty	3	188	Risk Ratio (M‐H, Random, 95% CI)	0.31 [0.16, 0.62]
1.11.2 Drug‐eluting balloon angioplasty	1	102	Risk Ratio (M‐H, Random, 95% CI)	0.11 [0.01, 0.85]
1.12 Amputation	3	178	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.01, 7.80]
1.12.1 Balloon angioplasty	2	76	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.01, 7.80]
1.12.2 Drug‐eluting balloon angioplasty	1	102	Risk Ratio (M‐H, Random, 95% CI)	Not estimable