TABLE 1.

Significant interactions between genus abundance and transcript expression

Microbiome groupa	Regulationb	Symbolc	Apoptosisd	GeneID	State	P valuef	FDRg
Cutibacterium	Downregulation	BIRC3	Yes	ENSG00000023445	−4.45	8.73E−06	0.06
Cutibacterium	Upregulation	KREMEN1	Yes	ENSG00000183762	4.49	7.14E−06	0.05
Cutibacterium	Upregulation	TGFBI	Yes	ENSG00000120708	4.39	1.13E−05	0.07
Staphylococcus	Downregulation	HTRA3	Yes	ENSG00000170801	−4.40	1.10E−05	0.07
Enterococcus	Upregulation	IL24	Yes	ENSG00000162892	5.01	5.55E−07	0.00
Clostridium_sensu_stricto_1	Downregulation	MMP3	Yes	ENSG00000149968	−4.33	1.46E−05	0.09
Clostridium_sensu_stricto_1	Upregulation	SLC12A8	No	ENSG00000221955	4.79	1.70E−06	0.01
Escherichia/Shigella	Upregulation	ITPRIP	Yes	ENSG00000148841	4.49	7.10E−06	0.05
Escherichia/Shigella	Downregulation	CALB2	Yes	ENSG00000172137	−4.90	9.48E−07	0.01
Escherichia/Shigella	Upregulation	IL11	Yes	ENSG00000095752	4.56	5.03E−06	0.03

^aThe microbiome group is the taxon at the genus level.

^bThe Regulation column indicates if the relationship between the taxon and the gene is one of downregulation or upregulation.

^cThe Symbol column shows the Entrez gene name.

^dThe Apoptosis column indicates if the gene has been associated with apoptosis in the literature.

^eThe Stat column shows the value of the Wald statistic (from DESeq2).

^fThe P value column shows the P value for the statistical test.

^gThe FDR column shows the false discovery rate (FDR)-corrected P value.