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a) Design schematic of combinatorial radio- and chemotherapy chitosan hydrogel b) delivered via injection. c) Radioactive leakage from alginate microparticles in chitosan matrix over 42 days demonstrates minimal (<1%) leakage (see insert). d) TMZ release from the chitosan matrix over 48 hours as well as e) survival of human GBM (D54) cell line during TMZ concentration study with TMZ-loaded hydrogels versus free TMZ.
Reproduced with permission.[53] 2018, Elsevier.
