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. 2021 Oct 13;41(41):8589–8602. doi: 10.1523/JNEUROSCI.0165-21.2021

Figure 6.

Figure 6.

Q175-FDN mice have altered circadian activity levels and impaired short-term motor learning. a, The average circadian distribution of trials (hourly bins) was significantly different in Q175-FDN and WT mice (p < 0.0001). Gray-shaded region represents the dark phase of the light cycle (7:00 P.M. to 7:00 A.M.). b, Q175-FDN (n = 14) mice performed significantly more trials per day compared with WT mice (n = 28). c, Q175-FDN mice (n = 14) had a greater number of trial bouts per day compared with WT mice (n = 28). d, Reward rate increased over the course of a bout in both WT (p = 0.0004) and Q175-FDN mice (p = 0.0006), although it was significantly lower in Q175-FDN overall (p = 0.0001). Reward rate was calculated for a 5-trial window centered on the indicated trial position (e.g., Trials 1-5 for Trial 3). e, The Fano factor of pull amplitude decreased over the course of a bout in WT (p = 0.0002), but not Q175-FDN mice (p = 0.26) and was significantly higher in Q175-FDN mice overall (p = 0.005). Fano factor was calculated for a 5-trial window centered on the indicated trial position. All data are from mice tested on the amplitude task and are presented as mean ± SEM.