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. 2021 Oct 13;41(41):8589–8602. doi: 10.1523/JNEUROSCI.0165-21.2021

Figure 7.

Figure 7.

PiPaw training reduces genotype differences in glutamatergic input to DLS-MSNs. a, sEPSC frequency recorded from DLS-MSNs in 10-month-old WT and Q175-FDN mice who were either trained on the PiPaw task or task-naive (n = 22(4) WT Naive, 31(5) Q175-FDN Naive, 53(8) WT Trained, 42(5) Q175-FDN Trained). sEPSC frequency is strongly reduced in neurons from naive Q175-FDN mice, but no genotype differences are seen after training. b, sEPSC amplitude in DLS-MSNs is similar between genotypes and in naive versus PiPaw-trained mice (n = 22(4) WT Naive, 31(5) Q175-FDN Naive, 53(8) WT Trained, 42(5) Q175-FDN Trained). Right, Representative traces. c, PPR recorded from DLS-MSNs in task-naive WT and Q175-FDN mice (n = 42(7) WT, 24(5) Q175-FDN). PPR is significantly higher in Q175-FDN mice at the shortest interstimulus interval, indicating a lower presynaptic probability of release. d, PPR is not different in DLS-MSNs from PiPaw-trained WT and Q175-FDN mice (n = 38(6) WT, 28(5) Q175-FDN). Right, Representative traces (stimulation artifact removed for clarity).