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. 2021 Oct 13;41(41):8589–8602. doi: 10.1523/JNEUROSCI.0165-21.2021

Figure 9.

Figure 9.

Behavioral and electrophysiological alterations are not present in young Q175-FDN mice. a, Young (3-month-old) Q175-FDN mice have normal learning of the PiPaw amplitude task across 1 week of testing. b, Average pull amplitude is similar in WT and Q175-FDN mice across 1 week of testing. c, The Fano factor of pull amplitude decreases to a similar extent in WT and Q175-FDN mice across 1 week of testing. d, The frequency of spontaneous EPSCs recorded in DLS-MSNs from mice trained on the PiPaw task was not significantly different in the left versus right hemisphere in either WT (p = 0.19) or Q175-FDN mice (p = 0.39) at 3 months of age, and no genotype differences were found (n = 14(4) WT LH, 16(4) WT RH, 17(5) Q175-FDN LH, 17(5) Q175-FDN RH). e, sEPSC amplitude was significantly lower in the left hemisphere (contralateral to the trained forelimb) compared with the right hemisphere in both WT (p = 0.047) and Q175-FDN mice (p = 0.003) (n = 14(4) WT LH, 16(4) WT RH, 17(5) Q175-FDN LH, 18(5) Q175-FDN RH). Right, Representative traces. All PiPaw data are from mice tested on the amplitude task and are presented as mean ± SEM.