Table 2. Correlation between DVL-1 expression and markers of immune cells in breast cancer.
| DESCRIPTION | GENE MARKERS | BRCA-LUMINAL (N = 611) |
BRCA-HER2 (N = 67) |
BRCA-TNBC (N = 139) |
|||
|---|---|---|---|---|---|---|---|
| Cor | p-value | Cor | p-value | Cor | p-value | ||
| B cell | CD19 | 0.0046597 | 0.913494164 | 0.04140914 | 0.75549825 | –0.2261982 | 0.00994861 |
| CD79A | –0.009124 | 0.831542125 | –0.0369959 | 0.780375818 | –0.228835 | 0.00922312 | |
| T cell | CD3D | –0.064502 | 0.132244282 | 0.00362361 | 0.978376301 | –0.1580445 | 0.07368264 |
| CD3E | –0.080455 | 0.060284068 | –0.02782 | 0.83398407 | –0.1568426 | 0.075923183 | |
| CD2 | –0.113064 | 0.008184703 | –0.0606078 | 0.647581519 | –0.1818146 | 0.039320345 | |
| CD8+ T cell | CD8A | –0.03664 | 0.392840297 | –0.0257744 | 0.84604819 | –0.1445886 | 0.10204675 |
| CD8B | –0.034776 | 0.417378575 | 0.03395675 | 0.798031544 | –0.1904908 | 0.030732045 | |
| Monocyte | CD86 | –0.184081 | 1.50E-05 | –0.1161309 | 0.380095014 | –0.1938562 | 0.027859995 |
| TAM | CCL2 | –0.157796 | 0.000213974 | –0.1717709 | 0.192803141 | –0.1507156 | 0.088214723 |
| CD68 | –0.128764 | 0.002574535 | –0.1036821 | 0.433507679 | –0.1358844 | 0.1245725 | |
| IL10 | –0.168813 | 7.37E-05 | –0.1654004 | 0.210021842 | –0.1524877 | 0.084506427 | |
| M1 Macrophage | NOS2 | –0.042345 | 0.323336377 | 0.16306254 | 0.21660626 | –0.0284018 | 0.749342348 |
| IRF5 | –0.017485 | 0.683516701 | –0.0199299 | 0.880703304 | 0.02967352 | 0.738194431 | |
| M2 Macrophage | CD163 | –0.032746 | 0.445096892 | –0.0987142 | 0.455954581 | –0.1455557 | 0.099756256 |
| VSIG4 | –0.046773 | 0.2752668 | –0.1527177 | 0.247486008 | –0.1207122 | 0.17277137 | |
| MS4A4A | –0.17308 | 4.79E-05 | –0.1997078 | 0.129210713 | –0.1813953 | 0.039782018 | |
| Neutrophils | CEACAM8 | –0.071667 | 0.094339597 | –0.2079493 | 0.1140052 | 0.09022021 | 0.309245703 |
| ITGAM | –0.074594 | 0.081605213 | –0.0712449 | 0.590899586 | –0.0992621 | 0.262681878 | |
| CCR7 | –0.016194 | 0.705759969 | 0.12893045 | 0.329528208 | –0.2000503 | 0.023170596 | |
| Natural killer cells | KIR2DL1 | –0.060979 | 0.154757284 | –0.018518 | 0.889285542 | –0.0911521 | 0.30425437 |
| KIR2DL3 | –0.056307 | 0.188932789 | 0.11967614 | 0.366615011 | –0.0386566 | 0.663603305 | |
| KIR3DL1 | –0.039552 | 0.356299066 | –0.0896774 | 0.499389981 | –0.0798297 | 0.368491565 | |
| KIR3DL2 | –0.086955 | 0.042250171 | –0.1985213 | 0.131736054 | –0.0858284 | 0.333483855 | |
| KIR3DL3 | 0.0081237 | 0.849785527 | –0.1086901 | 0.412539191 | –0.0930139 | 0.2944418 | |
| KIR2DS4 | 0.0030185 | 0.943898316 | –0.0161586 | 0.903319451 | –0.0453363 | 0.609931269 | |
| Dendritic cells | HLA-DPB1 | –0.009933 | 0.816870427 | 0.07083577 | 0.593037817 | –0.1180344 | 0.182549654 |
| HLA-DQB1 | –0.04385 | 0.30641251 | –0.1990064 | 0.130582081 | –0.131032 | 0.138700884 | |
| HLA-DRA | –0.139387 | 0.001092725 | –0.0933372 | 0.480955449 | –0.2016156 | 0.022099154 | |
| HLA-DPA1 | –0.144852 | 0.00068664 | –0.1326125 | 0.315812219 | –0.2183699 | 0.01305403 | |
| CD1C | –0.035466 | 0.408186814 | –0.0167787 | 0.899628151 | –0.1750478 | 0.047238406 | |
| ITGAX | –0.061916 | 0.14850528 | –0.0524839 | 0.692286752 | –0.157178 | 0.075292444 | |
| Th1 | TBX21 | –0.012384 | 0.77279054 | 0.00233781 | 0.986110628 | –0.1281138 | 0.147767936 |
| STAT4 | –0.13986 | 0.001050299 | –0.0388662 | 0.769565062 | –0.2236583 | 0.010972081 | |
| STAT1 | –0.171199 | 5.80E-05 | –0.1323203 | 0.316887168 | –0.1865105 | 0.034450435 | |
| IFNG | –0.08096 | 0.058685485 | –0.0765676 | 0.564351067 | –0.1353733 | 0.126108217 | |
| TNF | –0.015774 | 0.713045283 | –0.0979544 | 0.459443231 | 0.00626677 | 0.943753154 | |
| Th2 | GATA3 | 0.1219274 | 0.004328742 | 0.31367621 | 0.015894689 | 0.01678779 | 0.850042493 |
| STAT6 | 0.0940068 | 0.028059394 | –0.051315 | 0.698811092 | –0.0821165 | 0.354419627 | |
| STAT5A | 0.0930258 | 0.029747692 | –0.0558738 | 0.673493808 | –0.0993683 | 0.262169585 | |
| IL13 | –0.046235 | 0.280832776 | 0.12899372 | 0.330207686 | –0.0797132 | 0.369193244 | |
| Tfh | BCL6 | 0.0373671 | 0.383509691 | –0.1253653 | 0.34316356 | –0.0040977 | 0.963212664 |
| IL21 | –0.104767 | 0.014317684 | –0.1158771 | 0.382132421 | –0.1251018 | 0.157770632 | |
| Th17 | IL17A | –0.007988 | 0.852266864 | –0.074007 | 0.577486223 | –0.0743762 | 0.402205084 |
| Treg | FOXP3 | –0.059286 | 0.166554166 | –0.018761 | 0.887663456 | –0.1243907 | 0.15997923 |
| CCR8 | –0.135538 | 0.001501096 | –0.0609585 | 0.645678164 | –0.1927225 | 0.028658177 | |
| STAT5B | 0.0513082 | 0.231329692 | –0.0804793 | 0.54358993 | –0.2325973 | 0.008111482 | |
| TGFB1 | 0.045913 | 0.284197029 | 0.24003507 | 0.067250011 | –0.0750671 | 0.397345376 | |
| Tcell exhaustion | PDCD1 | 0.0406328 | 0.343298604 | 0.10829924 | 0.413218902 | –0.0703797 | 0.428032756 |
| CTLA4 | –0.112693 | 0.00839852 | –0.0345412 | 0.794628038 | –0.1629025 | 0.065166522 | |
| HAVCR2 | –0.202982 | 1.74E-06 | –0.1271186 | 0.336414085 | –0.1977862 | 0.024799287 | |
| GZMB | –0.0604 | 0.158714516 | –0.0142022 | 0.914884465 | –0.1138363 | 0.198957762 | |
Investigating the correlation between expression of DVL-1 with immune infiltration levels in breast cancer using TIMER. Bold values indicate the p-value < 0.05 with moderate correlation. RNA-Seq data from TCGA database is used to detect and quantify the immune infiltration levels in breast tumor subtypes.