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. Author manuscript; available in PMC: 2021 Oct 13.
Published in final edited form as: Chembiochem. 2014 Aug 22;15(14):2087–2096. doi: 10.1002/cbic.201402042

Scheme 3.

Scheme 3.

Synthesis of 3, 4, and 5. Detailed reaction conditions and reagents: a) 12, Pd(dppf)Cl2∙CH2Cl2, K2CO3, PhMe/H2O (2:1), microwave heating 120 °C, 30 min; b) PPTS, MeOH/CH2Cl2 (2:1), reflux, 2 h; c) Pd2(dba)3, DavePhos, bis(pinacolato)diboron, KOAc, 1,4-dioxane, microwave heating at 110 °C, 30 min; d) 11, Pd(dppf)Cl2∙CH2Cl2, K2CO3, PhMe/H2O (2:1), microwave heating at 120 °C, 30 min; e) 12, Pd2(dba)3, DavePhos, Cs2CO3, 1,4-dioxane/H2O (10:1), microwave heating at 80 °C, 30 min.