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. Author manuscript; available in PMC: 2021 Oct 13.
Published in final edited form as: ACS Biomater Sci Eng. 2018 Sep 17;4(10):3561–3569. doi: 10.1021/acsbiomaterials.8b00775

Figure 1.

Figure 1.

Schematic and characterization of dual-gradient hydrogels. (A) Schematic representation of the dual-gradient hydrogel design mimicking the trend of stiffness and sGAG content in native cartilage extracellular matrix. (B) Compressive modulus increased from zone 1 (9 kPa) to zone 5 (125 kPa) in dual-gradient hydrogels. (C) sGAG content increased from zone 1 to zone 5. Statistical analyses were performed using one-way analysis of variance (ANOVA), with Benjamin-Hotchberg correction for multiple posthoc comparisons of all adjacent zones. n = 3/group; *P < 0.05.