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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: J Neurosci Methods. 2021 Jun 24;360:109270. doi: 10.1016/j.jneumeth.2021.109270

Fig. 5:

Fig. 5:

Longitudinal registration step. T2-BL, -Y1 (T2-weighted image, FLAIR, baseline, one-yearvisit). T1-BL, -Y1 (T1-weighted image, baseline, one-year-visit). DF, deformation field. LR, longitudinal registration. The T2-weighted FLAIR images (T2-BL and rT2-Y1) from the preregistration step registered longitudinally to generate the midpoint image (T2-Midpoint) and the deformation field of each time point (DF-Y1 and DF-BL). Applying the deformation filed of each time point to register all images to the midpoint image, to get the longitudinal registered images (LR-T2-BL, LR-T1-BL, LR-T2-Y1, and LR-T2-Y1).