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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Nature. 2021 Jun 30;595(7868):606–610. doi: 10.1038/s41586-021-03686-x

Fig. 4: A revised flip state model.

Fig. 4:

(a) Non-cooperative binding model with a reversible conformational flip at each subunit following ligand binding (L). Grey box indicates alternative binding patterns. (b) Optimized transitions rates of a HCN1SM and HCN2SM. Errors are s.e.m. (c) Binding curve of HCN1SM and HCN2SM at various fcAMP concentrations overlaid with predictions from a (mean ± s.d.). Number of molecules for each fcAMP concentration is provided in Supplementary Table 1. (d) Hypothesized scheme wherein each subunit independently converts between unbound (U), bound (B), and flipped (B*) states.