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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Nature. 2021 Jun 30;595(7868):606–610. doi: 10.1038/s41586-021-03686-x

Extended Data Fig. 5: All state occupancy distributions:

Extended Data Fig. 5:

Normalized state occupancy distributions for HCN1SM (a) and HCN2SM (b) across all recorded fcAMP concentrations. Each plot indicates the total number of molecules (n) and data points (i.e., frames, m) included in the analysis. P is the success rate of the optimized binomial distribution considering four binding sites. All obtained and expected state occupancies values are in Supplementary Table 2.