Table 2:

End-Organ Perfusion during CICU stay by CS Type

Median (25th-75th), unless otherwise noted	De Novo HF-CS N=370	Acute-on-Chronic HF-CS N=1035	P-value*	AMI-CS N=688
Perfusion Markers
Lactate, mmol/L	3.9 (1.9-8.0)	2.7 (1.7-4.8)	<0.01	4.2 (2.2-8.0)
Lactate≥4 mmol/L, n(%)	164 (49.4%)	284 (31.8%)	<0.01	312 (51.8%)
Arterial pH	7.3 (7.2-7.4)	7.4 (7.3-7.4)	<0.01	7.3 (7.2-7.4)
Total bilirubin, mg/dL	1.2 (0.7-2.2)	1.6 (0.9-2.8)	<0.01	1.0 (0.6-1.6)
Creatinine, mg/dL	1.8 (1.2-2.9)	2.1 (1.5-3.2)	<0.01	1.8 (1.3-3.2)
ALT, mg/dL#	88.0 (40.0-425.0)	53.0 (25.0-239.0)	<0.01	88.0 (45.0-327.0)
AST, mg/dL#	135.0 (54.0-702.0)	65.5 (33.0-269.0)	<0.01	229.0 (87.0-749.0)
ALT≥150 and/or AST≥150# n(%)	104/213 (48.8%)	222/627 (35.4%)	<0.01	255/403 (63.3%)
SOFA score≥8	191 (51.6%)	423 (40.9%)	<0.01	382 (55.5%)

^*P-value indicates the comparison between de novo HF-CS and acute-on-chronic HF-CS.

ALT = alanine aminotransferase; AST = aspartate aminotransferase; HF-CS = Heart failure associated cardiogenic shock; AMI-CS = acute myocardial infarction related cardiogenic shock; SOFA = Sequential Organ Failure Assessment

^#Data available for a subset of all patients.